Learn how epitope mapping and membrane proteome-wide specificity profiling can elevate the value of monoclonal antibodies
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Webinar:
 
Detailed Antibody Characterization Enabled by High Throughput Flow Cytometry

Learn how epitope mapping and membrane proteome-wide specificity profiling can elevate the value of monoclonal antibodies

Abstract:

Detailed antibody characterization is a critical component of the discovery process for therapeutic monoclonal antibodies (MAbs). Epitope data informs mechanism-of-action and lead candidate selection, and is valuable for obtaining MAb patent protection. Detailed antibody specificity analysis is crucial for predicting clinical safety by identifying off-target interactions, thereby de-risking antibody therapeutic development.

Integral Molecular has developed innovative solutions such as Shotgun Mutagenesis Epitope Mapping and the Membrane Proteome Array for characterizing antibodies against cell surface targets. These assays are run on Intellicyt’s sensitive, high-throughput flow cytometry platform to detect MAb binding to proteins natively expressed on cells.

Webinar Highlights:

  • How epitope mapping data can elevate the value of monoclonal antibodies through mechanism-of-action insights and enhanced intellectual property
  • Case studies demonstrating how detailed specificity analysis can reveal off-target antibody interactions, and de-orphan antibodies obtained through functional screening
  • How Intellicyt’s platform provides reproducible generation of high-throughput data, enabling the high success rate of Epitope Mapping and Membrane Proteome Array technologies

DATE:
October 19th, 2017

TIME:
08:00 a.m. PT
11:00 a.m. ET
04:00 p.m. GMT

DURATION:
60 Minutes

Register Now

Speakers:

Rachel Fong
Project Leader, Epitope Mapping, Integral Molecular

Rachel Fong is the Project Leader for Shotgun Mutagenesis Epitope Mapping at Integral Molecular. Ms. Fong will provide an overview of Integral Molecular’s Shotgun Mutagenesis epitope mapping platform and discuss case studies of how this technology is able to map complex conformational epitopes with >95% success on even the most challenging membrane protein targets including GPCRs, ion channels, immuno-oncology targets, and viral proteins. She will also describe how this data helps to fulfill specific requirements for antibody patents.

Duncan Huston-Paterson, D Phil
Project Leader, Membrane Proteome Array, Integral Molecular 

Duncan Huston-Paterson is a Project Leader at Integral Molecular, responsible for guiding the development of the Membrane Proteome Array platform for applications in novel therapeutic target discovery, antibody deorphaning, and off-target safety profiling. Dr. Huston-Paterson will provide an overview of Integral Molecular’s Membrane Proteome Array. He will discuss applications of this technology for antibody specificity profiling and antibody de-orphaning, providing case studies of how these analyses provided critical and sometimes surprising insights into antibody specificity.

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